
Enteric Nervous System (ENS)
The enteric nervous system is the neural network embedded within the walls of your gastrointestinal tract — from oesophagus to rectum. It contains more than 500 million neurons, making it the most complex neural network in the body outside the brain itself. This is why scientists sometimes call it the second brain, though that phrase understates how extraordinary it actually is.
Unlike most of the body’s systems, the ENS can operate entirely independently. It doesn’t need instruction from your brain to run digestion, regulate gut motility, control the secretion of enzymes, or manage blood flow to your intestinal walls. It does all of this on its own, without you having to think about it once.
But independent does not mean isolated. The ENS is connected to the brain via the Vagus Nerve — the longest cranial nerve in the body, running from brainstem to abdomen — and through this connection your gut and brain are in constant two-way conversation via the Gut-Brain Axis. The majority of that traffic, around 80%, travels upward: from gut to brain, not the other way around. Your gut is not simply receiving instructions. It is sending them.
What governs the quality of that conversation is largely what you feed your Gut Microbiome. The bacteria in your gut produce Short Chain Fatty Acids, neurotransmitter precursors, and neuroactive Metabolites — including the precursors to Serotonin, dopamine, and GABA — that stimulate the ENS and influence signalling all the way to the brain. More than 90% of the body’s serotonin is produced in the gut. It cannot cross the blood-brain barrier directly, but its precursor Tryptophan can, and the microbiome plays a central role in regulating that pathway.
This is why the composition of your bread matters neurologically, not just digestively. Long-Fermented, Fibre-rich, Polyphenol-rich, botanically diverse bread feeds the bacterial communities that produce these metabolites. Mono bread — stripped of fibre, fermentation and diversity — starves them. The ENS notices. So does the brain it is talking to.
There is a second dimension to this that is equally important and less often discussed. The ENS is exquisitely sensitive to threat. When the body activates the sympathetic nervous system — fight or flight — vagal tone drops, gut motility slows, beneficial bacteria decline and Dysbiosis takes hold. Inflammation increases, Cortisol rises, and the integrity of the gut lining is compromised. You cannot absorb nutrients properly, you cannot produce neurotransmitter precursors efficiently, and you cannot heal in a state of threat. The ENS requires safety to function well. This is not a metaphor. It is physiology.
The act of baking addresses this at both ends simultaneously: the bread feeds the microbiome that supports ENS function, and the ritual of baking itself — slow, rhythmic, sensory, grounding — activates the Parasympathetic Nervous Systemthrough which that function is restored. This is the foundation of the BALM Protocol.
See also: Vagus Nerve, Gut-Brain Axis, Short Chain Fatty Acids, Serotonin, Dysbiosis, BALM Protocol
TGR5 (Takeda G Protein-Coupled Receptor 5) and Energy Balance