The Sourdough School

Specialising in Nutrition & Digestibility of Bread & the Gut Microbiome

Learn to make Sourdough & discover why sourdough is the healthiest bread. Find out how sourdough helps your digestion & benefits to your overall health & wellbeing. It is about making connections, & the mindfulness & joy of baking, as well as understanding the techniques that make your bread rise so you can bake & share nourishing bread every day, with the people you love.
Follow on Instagram

+44 (0)7707 480336
+44 (0)1604 881274
bookings@sourdough.co.uk
Follow on Instagram
  • Facebook
  • Instagram
  • Pinterest
  • Twitter
Soil Association
We are certified organic by the soil association.
Navigation
  • Home
  • Courses
    • Basic – join the club
    • Online Diploma
    • Online Diploma + 1 Week in Person
    • Diploma Course Waiting List
    • Attending the School in person Information
    • My Bookings
  • The School
    • Sourdough School Events
    • Vanessa Kimbell
    • The Team
    • Sourdough School Events
    • Reviews
    • Press Enquires
    • Newsletter
    • Terms for The Sourdough School Ltd
  • The Club
  • Learn
    • To Make Sourdough
    • Ingredients
    • Recipes
    • Eating Symbiotically
    • Research Database
    • Connections
    • Glossary
    • Gallery
  • Health
    • Sweet Sourdough Gut Microbiome Trial
    • Digestion
    • Nutrition
    • Gut Microbes
    • Prebiotics
    • Probiotics
    • Case Studies
  • Shop
    • Books
    • Equipment
    • Ingredients
  • Login

436 - ‘Metabolomic response to coffee consumption application toa three-stage clinical trial’. Journal of Internal Medicine. 283(6): P544-557

Reference Number: 436

Year: 2018

Authors: M. C. Cornelis, Erlund G, A Michelotti, C. Herder, J. A. Westerhuis, J. Tuomilehto

Link: Link to original paper

Nutrition: Polyphenols | Prebiotic

Summary

Background

Coffee is widely consumed and contains many bioactive compounds, any of which may impact pathways related to disease development.

Objective

To identify individual metabolite changes in response to coffee.

Methods

We profiled the metabolome of fasting serum samples collected from a previously reported single?blinded, three?stage clinical trial. Forty?seven habitual coffee consumers refrained from drinking coffee for 1 month, consumed four cups of coffee/day in the second month and eight cups/day in the third month. Samples collected after each coffee stage were subject to nontargeted metabolomic profiling using UPLC?ESI?MS/MS. A total of 733 metabolites were included for univariate and multivariate analyses.

Results

A total of 115 metabolites were significantly associated with coffee intake (P < 0.05 and Q < 0.05). Eighty?two were of known identity and mapped to one of 33 predefined biological pathways. We observed a significant enrichment of metabolite members of five pathways (P < 0.05): (i) xanthine metabolism: includes caffeine metabolites, (ii) benzoate metabolism: reflects polyphenol metabolite products of gut microbiota metabolism, (iii) steroid: novel but may reflect phytosterol content of coffee, (iv) fatty acid metabolism (acylcholine): novel link to coffee and (v) endocannabinoid: novel link to coffee.

Conclusions

The novel metabolites and candidate pathways we have identified may provide new insight into the mechanisms by which coffee may be exerting its health effects.

 

Significance of this study:

This shows that in some people, coffee may exert positive health benefits due to its polyphenol content, and the metabolism of these polyphenols by the gut microbiota.

See our online learning course on The Sourdough Club

Share the post "Metabolomic response to coffee consumption application toa three-stage clinical trial"

  • Facebook
  • Twitter
  • Google+
  • E-mail
Follow on Instagram
This error message is only visible to WordPress admins

Error: No posts found.

Make sure this account has posts available on instagram.com.

  • Facebook
  • Instagram
  • Pinterest
  • Twitter

Email Sign Up:

Privacy and Cookies

Copyright © 2021 Vanessa Kimbell | Login
Call +44 (0)7707 480336 | +44 (0)1604 881274 - Email bookings@sourdough.co.uk
Registered in England and Wales: 08412236
Website by Callia Web