Reference Number: 22
The aim of the present study was to exam- ine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and in ammatory risk factors, and in restoring blood redox bal- ance in type 2 diabetes mellitus (T2DM) patients compared to diet with product made with modern organic wheat.
We conducted a randomized, double-blinded crossover trial with two intervention phases on 21 T2DM patients (14 females, 7 males). The participants were assigned to consume products (bread, pasta, crackers and biscuits) made using semi-whole our from organic wheat that was either from ancient khorasan wheat or modern control wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interven- tions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase.
The metabolic risk pro le improved only after the khorasan intervention period, as measured by a reduc- tion in total and LDL cholesterol (mean reduction: ?3.7 and ?3.4 %, respectively), insulin (?16.3 %) and blood glucose (?9.1 %). Similarly, there was a signi cant reduc- tion in circulating levels of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin- 1ra, and a signi cant increase of total antioxidant capacity (+6.3 %). No signi cant differences from baseline were noted after the modern control wheat intervention phase. The change (from pre- to post-intervention) between the two intervention arms was signi cantly different (p < 0.05) for total and LDL-c, insulin and HOMA index.
SIGNIFICANCE OF THIS STUDY
The present study is the second study that evaluated the functional efficacy of organic ancient wheats such as khorasan in a population with a chronic disease. The study reported a positive impact of khorasan wheat products on blood insulin and glucose. A replacement diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose compared to a diet with products made with modern wheat. Khorasan can be easily adapted into your daily diets by baking your sourdough loaves with ancient wheats such as khorasan as a suitable measure to help prevent or manage chronic diseases.