Reference Number: 47
A considerable amount of evidence indicates that tumorigene- sis is associated with inflammation. Nuclear factor-kappa B (NF- ?B), a master regulator of infection and inflammation, has been identified as a key modulator in which inflammation could de- velop into cancer. Dietary polyphenols have been shown to have anti-inflammatory and anticancer activity partially through in- hibition of NF-?B activation.
SIGNIFICANCE OF THIS STUDY
The current review summarizes the effect of polyphenols on inflammation and cancer with special focus on avenanthramides which is a unique polyphenol found in oats.One of the foods with potential anticancer properties is oats and due to a high content of ?-glucan which is a soluble fibre, oats and oat bran have been known sceintifically to reduce blood cholesterol, reduce the risk of cardiovascular disease and may also help to prevent colon cancer . In addition, other studies have reported that an oat-containing, hypocaloric diet reduced systolic blood pressure and improved lipid profile beyond effects of weight loss in men and women. Evidence therefore suggests that unprocessed oats can have beneficial effects on overall health and wellbeing and we at the sourdough school often incorporate oats in several of our recipes.